Move the microphone to the next position and push F2 to perform a new measurement, then save the measurement. Repeat this procedure till you have saved 5 measurements (or another number if you did not set the total number to 10 measurements during the preparation).
Now move the loudspeaker to a new position and perform measurements in the same 5 microphone positions.
Note: If you do not save exactly the number of measurements that is set in Measurement->Saving Defaults... during the preparation, the saving default naming will be difficult to follow. (If you want to perform extra measurements for testing/comparison you can wait with saving these until you have finished all measurements)