Yes, with loop-back and end-check

The measurement is performed using a physical loop-back, usually connected from output right channel to input right channel.

A pulse is sent through the loop-back before the measurement is performed and it makes it possible to determine the initial time delay correctly.

Also after the measurement is finished, a pulse is sent through the loop-back. The time delay between this pulse and the pulse sent before the measurement was started is checked. This end-check is used to detect errors in the measurement caused by gaps or errors in play or record (this may happen e.g. if the PC is used for other things while the measurement is performed). The synch. Signal settings (see section below) must be properly set.

For a more detailed explanation see Measurement 6: Measure in a safe way using loop-back in the section The first measurements walk-through.